Naloxone, which reverses the effects of opioids, was synthesized in 1960, though the hunt for opioid antagonists began a half-century earlier. The history of this quest reveals how cultural and medical attitudes toward opioids have been marked by a polarization of discourse that belies a keen ambivalence. From 1915 to 1960, researchers were stymied in seeking a “pure” antidote to opioids, discovering instead numerous opioid molecules of mixed or paradoxical properties. At the same time, the quest for a dominant explanatory (...) and therapeutic model for addiction was likewise unsettled. After naloxone’s discovery, new dichotomizing language arose in the “War on Drugs,” in increasingly divergent views between addiction medicine and palliative care, and in public debates about layperson naloxone access. Naloxone, one of the emblematic drugs of our time, highlights the ambivalence latent in public and biomedical discussions of opioids as agents of risk and relief. (shrink)

Explores the relationships among hypertext, rhetoric, and philosophy.

A collection of essays presented at "Frater, Magister, Minister, Episcopus. The Works and Worlds of Bonaventure," a conference held at St. Bonaventure University, commemorating the 800th Centennial of Saint Bonaventure, the Seraphic Doctor.

In lieu of an abstract, here is a brief excerpt of the content:American Journal of Philology 123.3 (2002) 529-534 [Access article in PDF] Colin Adams and Ray Laurence, eds. Travel and Geography in the Roman Empire. London and New York: Routledge, 2001. x + 202 pp. 48 black-and-white figures. Cloth, $75. Five of the six contributions to this varied and valuable collection of essays originated as papers delivered at the 1999 Roman Archaeology Conference in Durham, England. The sixth and longest (...) piece, by Benet Salway, was then added, together with an introduction by one co-editor (Adams) and an afterword by the [End Page 529] other (Laurence). Notes follow each contribution, with a consolidated bibliography and index at the end. Although in black and white only, the range of photos, figures, and maps is appropriately extensive.The volume stems from due recognition that geographical knowledge and travel in the Roman world are topics at last attracting the serious attention they deserve. Between them, the contributions amply demonstrate how even some of the aspects most fundamental to our understanding stir deep controversy and how incomplete the exploitation of much of the diverse source material has been to date. Happily, the emergence of exciting new discoveries is prompting fresh examination of testimony long known and neglected.Useful, though limited in scope, is Anne Kolb's "Transport and Communication in the Roman State: The cursus publicus" (95-105), which mainly confines itself to identifying those categories of imperial officials and other individuals entitled to use the service (more properly referred to as vehiculatio during the Principate). By contrast, the support Kolb offers for the doubtful claim that transport of freight—other than baggage accompanying officials—was a "relatively unimportant" aspect of the service, even in the Late Empire (102), remains inadequate. Throughout, changes to the service over such a long span seem underappreciated (not least, for example, Nerva's removal of the burden from Italy).Adams modestly characterizes his contribution "'There and Back Again': Getting around in Roman Egypt" (138-66) as descriptive rather than analytical. His aim is to demonstrate the scope and value of the testimony preserved on papyri, and he does this engagingly, with unfailing regard for the impact of Egypt's unique geography and topography on travel there. Even though its publication dates back to 1952, few readers are likely to be familiar with the extensive archive preserving an itinerary and accounts for Theophanes' return journey from Antinoopolis to Antioch around 320 (160-62). Even fewer will be aware of the record of travelers and animals accommodated overnight, and rations issued to them, kept by the two large, busy mansiones in the Oxyrhynchite nome during the mid-fourth century and only published in 1994 (142-44). Vivid illustration of the multiple hazards awaiting travelers by road from causes both natural and human (154-56) can serve as a sobering counterbalance to the ideal conditions evoked by Aelius Aristides and quoted earlier by Adams (as eulogy) in the Introduction (1-2). One manifestation of "recreational" travel, which seems strangely absent from the discussion, on page 157 in particular, is pilgrimage (note, in general, Der Neue Pauly, s.v. Pilgerschaft 1).Jon Coulston's "Transport and Travel on the Column of Trajan" (106-37) is another predominantly descriptive contribution but one well geared to substantiate its conclusion: "The conflict is not simply between Romans and Dacians, Trajan and Decebalus. It is also a contest between Romans and barbarians, disciplina and perturbatio, labor and inertia, imperial virtues and enemy perfidy, civilisation and untamed nature, urbanisation and wilderness" (129-30). Description, moreover, is justified here when no other piece of Roman propaganda art, [End Page 530] before or after, depicts armies on the move—tents (for which soldiers were charged! [Tacitus Annals 1.17.4]), carts, pack animals, equipment, provisions, along roads, over bridges—with such amazing fullness and detail. We possess no more forceful illustration of the huge "train" that had to accompany every legion (118-19; the comparison made with Ottoman armies on campaign in the sixteenth and seventeenth centuries is instructive). Coulston's acute observation, lucid presentation, and reluctance to overinterpret... (shrink)

This article attempts a contextual study of the origin and early development of August Kekulé's theory of aromatic compounds. The terminus a quo is essentially August Hofmann's coining of the modern chemical denotation of ‘aromatic’ in 1855; the terminus ad quem is the first full codification of Kekulé's theory in the sixth fascicle of his Lehrbuch der organischen Chemie, published in the summer of 1866. Kekulé's theory is viewed in context with the earlier and concurrent experimental work of such chemists (...) as Hermann Kolbe, Friedrich Beilstein, Rudolph Fittig, and Hugo Müller. The reception of the theory is briefly examined. Attention is paid to the role of Kekulé's molecular models and of his celebrated dream anecdote of the snake that seizes its own tail. The episode is used as a case study for the continuity of scientific progress, and to illustrate the close reciprocal interactions of hypothesis and experiment in the evolution of a scientific theory. (shrink)

Everyone has a different "learning style". (A good introduction to the topic of learning styles is Claxton & Murrell 1987. For more on different learning styles, see Keirsey Temperament and Character Web Site, William Perry's Scheme of Intellectual and Ethical Development, Holland 1966, Kolb 1984, Sternberg 1999. For an interesting discussion of some limitations of learning styles from the perspective of teaching styles, see Glenn 2009/2010.) For some online tools targeted at different learning styles, see "100 Helpful Web Tools (...) for Every Kind of Learner". (shrink)

Kolb's purpose is to dispel a practical and theoretical illusion--promoted by modernity about its own uniqueness as a unified and unifying constellation of meanings which wholly defines us--and to put modernity "in its place" within that sustaining and limiting context which makes it possible, which cannot be described in "standard modern terms," and which suggests that we are not as free as--and yet more than what--modernity says we are. He begins with an examination of the "standard self-description of modernity (...) and its basic dichotomies and divisions," in particular the modern preference for formal over substantive rationality, emphasized by Max Weber in his presentation of modern society as "a process waiting for content to come from the choice of its citizens"--the modern self relating "to itself and to others as a pure chooser, with no necessary substantive content". (shrink)

Den Menschen zu verstehen ist das zentrale Anliegen des Theologen, Philosophen und Psychologen Helmut Dorra – sowohl in der Lehre als auch in der existenzanalytischen, logotherapeutischen Praxis. Die Autor:innen dieser Festschrift beleuchten anlässlich seines siebzigsten Geburtstags wesentliche Thematiken seines Ansatzes und laden zum Kennenlernen sowohl der Person Helmut Dorra als auch des existenziellen Denkens ein. Vom mutigen Handeln im richtigen Augenblick über den Zwiespalt zwischen Sein und Sollen bis zur Trauer als existenziellem Prozess werden grundlegende Themen wie Dialog, Freiheit, Konflikt, (...) Person, Resonanz oder Solidarität theoretisch betrachtet und für die beratende und therapeutische Praxis nutzbar gemacht. Mit Beiträgen von Emmanuel J. Bauer, Helmut Dorra, Rahel Dorra, Daniela von Heyl, Elisabeth Kohrt, Christoph Kolbe, Georg Martensen, René Märtin, Mariola Niedzielska-Wagener, Daniel Rumel, Stefan Wagener und Julia Werner. (shrink)

A cross-sectional study to ascertain what the Singapore population would regard as material risk in the anaesthesia consent-taking process and identify demographic factors that predict patient preferences in medical decision-making to tailor a more patient-centered informed consent. A survey was performed involving patients 21 years old and above who attended the pre-operative evaluation clinic over a 1-month period in Singapore General Hospital. Questionnaires were administered to assess patients’ perception of material risks, by trained interviewers. Patients’ demographics were obtained. Mann–Whitney U (...) test and Kruskal-Wallis one-way analysis of variance was used. Statistical significance was taken at p < 0.05. Four hundred fourteen patients were eligible of which 26 refused to participate and 24 were excluded due to language barrier. 364 patients were recruited. A higher level of education, being employed and younger age group are factors identified in patients who wanted greater participation in medical decisions. Gender, marital status, type of surgery, and previous surgical history did not affect their level of participation. The complications most patients knew about were Nausea, Drowsiness and Surgical Wound Pain. Patients ranked Heart Attack, Death and Stroke as the most significant risks that they wanted to be informed about in greater detail. Most patients wanted to make a joint decision with the anaesthetist, instead of letting the doctor decide or deciding for themselves. Discussion with the anaesthetist is the preferred medium of communication compared to reading a pamphlet or watching a video. Age and educational level can influence medical decision-making. Despite the digital age, most patients still prefer a clinic consult instead of audio-visual multimedia for pre-operative anaesthetic counselling. The local population appears to place greater importance on rare but serious complications compared to common complications. This illustrates the need to contextualize information provided during informed consent to strengthen the doctor-patient relationship. (shrink)

Peter Kivy argues that Handel was the first composer to be regarded as a genius and that only in the eighteenth century was the philosophical apparatus in place that would enable any composer to be conceived of as a musical genius. According to Kivy, a Longinian conception of genius transformed Handel into a genius. A Platonic conception of genius was used to classify Mozart as a genius. Then Kant adopted a Longinian conception of genius and this shaped the perception of (...) Beethoven. Kivy is wrong on all counts. Composers were thought to be geniuses long before Handel. The emergence of philosophical aesthetics in the eighteenth century did little to shape conceptions of musical genius. More specifically, Kivy misrepresents Kant's conception of genius and the role that it plays in the recognition of Beethoven as a musical genius. (shrink)

Jian Zhou,* Weiqiang Ju,* Xiaopeng Yuan, Xiaofeng Zhu, Dongping Wang, Xiaoshun HeOrgan Transplant Center, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China *These authors contributed equally to this work: Hyperosmolar nonketotic hyperglycemic coma is a serious, rare complication induced by methylprednisolone pulse therapy for acute rejection after orthotopic liver transplantation. Herein, we report an unusual case of a 58-year-old woman who experienced acute rejection at 30 months after OLT, only one case in which HNKHC resulted in MP (...) pulse therapy for acute rejection in all 913 recipients in our center. The general morbidity of HNKHC was 1.09‰ in this study. HNKHC is characterized by rapid onset, rapid progression, and a lack of specific clinical manifestations. High-dose MP management was a clear risk factor. The principle of treatment included rapid rehydration, low-dose insulin infusion, and correcting disorders of electrolytes and acidosis. In conclusion, clinicians considering MP pulse therapy after OLT should be alert to the occurrence of HNKHC. Keywords: liver transplantation, complications, hyperosmolar nonketotic hyperglycemic coma, methylprednisolone pulse therapy, principle of treatment. (shrink)

The eleven essays collected here include three papers, written in the 1980s, on the influence of Hegel on Heidegger’s thinking by Jacques Taminiaux, Dominique Janicaud, and Michel Haar, respectively; a paper on Heidegger’s several readings of Hegel’s Phenomenology of Spirit by Robert Bernasconi ; two papers on Hegel’s aesthetics by Martin Donougho and John Sallis; a paper on Hegel’s philosophy of history by David Kolb; two papers on Hegel, Heidegger, and Antigone by Dennis J. Schmidt and Kathleen Wright; an (...) essay on unpublished notes by Friedrich Hölderlin, with references to Heidegger’s philosophy by David Farrell Krell; and a general introduction to the volume by one of its editors, John McCumber. The French papers, which are in the background of many of the remaining papers, have been previously published, as has the contribution by Krell, which is reprinted from an earlier volume with a few minor changes and the addition of a short paragraph. The paper by Sallis is based on a chapter from a previously published book that has been expanded to include a discussion of Hegel’s aesthetics. (shrink)

Nowadays, it is common that newly built hospitals are designed with single‐room accommodation, unlike in the past, where shared accommodation was the favoured standard. Despite this change in hospital design, very little is known about how single‐room accommodation affects nurses' work environment and nursing care. This study evaluates how the single‐room design affects nurses and nursing care in the single‐room hospital design. Nurses working in the single‐room design predominantly work alone with little opportunity for peer training, interaction and reflection. In (...) addition, the single‐room design affects the nurses' work environment due to changes in sensory stimulation and increased walking distances. Furthermore, a change in the discourse, namely, regarding the single room as the patient's home, makes the nurses react to queries, demands and tasks in a new way. Overall, the new hospital design forces the nurses into a more reactive role and affect their way of providing nursing care. Despite this, the nurses find single‐room accommodation beneficial for the patients and their nursing care. (shrink)

Corporate governance and finance are dynamic academic fields that offer myriad opportunities for business ethics analysis. Within the corporate governance triad in recent years, shareholders have increased their power over boards of directors and executives through both regulation and movements to change corporate by-laws. The impact of board characteristics on firm performance has proven elusive, leading to questions concerning board processes and individual director beliefs and behaviors. At the same time, CEOs have lost considerable power, leaving many struggling to regain (...) their control and maintain their compensation levels, while others adopt a stewardship approach to their posts. In the field of finance, the recent financial debacle has led to a reexamination of financial regulation and of the fundamental nature and purpose of the industry. All of these issues provide business ethicists fodder for investigation and analysis. (shrink)